

| Sheriff Andy Taylor: | Andy Griffith |
| Deputy Barney Fife: | Don Knotts |
| Opie Taylor, Andy's son: | Ronny Howard |
| Bee Taylor, Andy's aunt: | Frances Bavier |
| Gomer Pyle, filling station attendant: | Jim Nabors |
| Floyd Lawson, barber: | Howard McNear |
| Ellie Walker, druggist: | Elinor Donahue |
| Mary Simpson, nurse: | Sue Anne Langdon |
| Julie Adams | |
| Helen Crump, teacher: | Aneta Corsaut |
| Thelma Lou, Barney's girlfriend: | Betty Lynn |
| Otis Campbell, town drunk: | Hal Smith |
| Howard Sprague, county clerk: | Jack Dodson |
| Briscoe Darling, hillbilly: | Denver Pyle |
| Ernest T. Bass, trouble-maker: | Howard Morris |
| Goober Pyle, Gomer's cousin: | George Lindsey |
| Malcolm Merriweather, Englishman: | Bernard Fox |
| Clara Edwards: | Hope Summers |
| Deputy Warren Ferguson: | Jack Burns |
| Mayor Pike: | Dick Elliott |
| Mayor Stoner: | Parley Baer |
| Jim Lindsey, Guitar player: | James Best |
| Emma Brand, hypochondriac: | Cheerio Meredith |
| Sam Jones, councilman: | Ken Berry |
| Millie Swanson, Sam's girlfriend: | Arlene Golonka |
| Mike Jones, Sam's son: | Buddy Foster |
| Emmet Clark, fix-it shop owner: | Paul Hartman |
| Skippy, fun-loving girl: | Joyce Jameson |
| Daphne, fun-loving girl: | Jean Carson |
| Martha Clark, Emmet's wife: | Mary Lansing |
| Leon, boy with peanut butter sandwich: | Clint Howard |
| Johnny Paul, Opie's friend: | Richard Keith |
| Peggy McMillan, Andy's girlfriend: | Joanna Cook Moore |
| Mrs. Sprague, Howard's mother: | Mabel Albertson |
| Jud Crowley: | Burt Mustin |
| Irene Fairchild, county nurse: | Nina Shipman |
| Lydia Crosswaithe: | Josie Lloyd |
| Charlene Darling: | Maggie Peterson |
| Dud Wash: | Bob Denver |
| Gilly Walker: | Larry Hovis |
| Various roles: | Allan Melvin |
| Announcer: | Colin Male |





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